Pair Name	Baicalein, Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Phosphorylation	MAPK14	hsa1432
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Down-regulation	Expression	SLC7A6	hsa9057
In Vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0134
	A2780/CDDP	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_D619
	T29	Healthy	Homo sapiens (Human)	CVCL_2G67
In Vivo Model	Single cell suspensions from A2780, A2780/CDDP, A2780/CDDP shCirSLC7A6 or A2780/CDDP shGFP cells were injected (5.0×10⁶ cells/100 ul in phosphate buffered saline) subcutaneously into the bilateral interscapular region of the mice.
Result	Treatment with baicalein improved the sensitivity of ovarian cancer cells to cisplatin and inhibited cell proliferation, metastasis and tumor growth

Pair Name	Baicalein, Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis and autophagy
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	IKBKB	hsa3551
	Down-regulation	Activity	KEAP1	hsa9817
	Up-regulation	Expression	MAP1LC3B	hsa81631
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Down-regulation	Activity	NFE2L2	hsa4780
	Up-regulation	Phosphorylation	NFKBIA	hsa4792
	Down-regulation	Expression	RELA	hsa5970
	Down-regulation	Phosphorylation	SQSTM1	hsa8878
In Vitro Model	MGC-803	Gastric mucinous adenocarcinoma	Homo sapiens (Human)	CVCL_5334
	HGC-27	Gastric carcinoma	Homo sapiens (Human)	CVCL_1279
	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
Result	Baicalein enhanced cisplatin sensitivity of gastric cancer cells by inducing cell apoptosis and autophagy via Akt/mTOR and Nrf2/Keap 1 pathway